Mepolizumab is a monoclonal antibody that targets interleukin-5, a key cytokine in eosinophilic inflammation. The MATINEE trial ( NEJM 2025; doi: 10.1056/NEJMoa2413181) is a phase 3, double-blind, ...
Background Obstructive sleep apnoea (OSA) is a prevalent sleep disorder strongly associated with metabolic syndrome. Visceral adiposity is the principal culprit of the metabolic syndrome leading to ...
Objective Severe early-onset-chronic obstructive pulmonary disease (SEO-COPD) represents the most severe form of COPD that manifests at an earlier age than common COPD. We hypothesise that this is ...
A 62-year-old man with a history of systemic Amyloid light-chain (AL) amyloidosis in prior haematological remission presented with progressive dyspnoea and non-productive cough. He denied haemoptysis, ...
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Surveillance systems at the population level are of crucial importance to track diseases and detect trends over time. Among other benefits, these tools allow us to understand the distribution of ...
Introduction Physical exercise has been used to assist smoking cessation, but supervised programmes are bounded by limited ...
Background Current quantitative chest CT techniques improve chronic obstructive pulmonary disease (COPD) phenotyping but do not capture spatial variability and potentially reversible disease in local ...
Background Critical care medicine has historically relied on syndromic diagnoses such as sepsis, acute respiratory distress syndrome (ARDS) and acute kidney injury to guide research and treatment.
Background Fibrotic hypersensitivity pneumonitis (FHP) is an irreversible lung disease with high morbidity and mortality. We sought to evaluate the safety and effect of pirfenidone on disease ...
Objective To determine the diagnostic accuracy of point-of-care ultrasound in suspected pulmonary embolism. Design Systematic review and meta-analysis. Data sources MEDLINE, Embase, CINAHL and ...
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