ALS-causing NEK1 gene mutations disrupt cellular protein production machinery. Truncated NEK1 protein accumulates in the nucleolus, impairing ribosome biogenesis. This disruption leads to cell death ...

A new genetic study links higher levels of specific fat molecules to increased ALS risk. Fat metabolism in the body was identified as a relevant pathway in ALS susceptibility. The scientists say ...

Bulbar-onset ALS is diagnosed about four months sooner than limb-onset ALS. Limb-onset ALS is often misdiagnosed, delaying critical treatment and care. Awareness strategies for limb-onset ALS can ...

The U.S. House of Representatives has passed legislation that would renew the ACT for ALS, a landmark federal law that supports amyotrophic lateral sclerosis (ALS) research and helps people with the ...

The Muscular Dystrophy Association (MDA) brought its Engage Community Seminar to Hershey, Pennsylvania, on July 18, uniting ...

Of all the scenes that stay in my mind from my late husband Jeff’s time with ALS, this is among the most enduring: Jeff, wearing a Navy baseball cap and a weathered T-shirt, sitting behind the console ...

While the findings align with previous research linking smoking to ALS, researchers found no consistent evidence that heavier ...

An AI-powered brain implant helped an ALS patient regain speech by decoding brain signals. This neuroprosthesis translates ...

RAG-17 is an experimental RNA-targeting therapy designed to lower toxic SOD1 protein in people with SOD1-ALS. A six-person trial found RAG-17 was well tolerated, with no serious side effects. RAG-17 ...

The approval of a gene-targeted therapy for ALS has revolutionized genetic testing in Canada, a study found. All ALS patients, including those with no family history, are now routinely offered genetic ...

ALS has taken a lot, but I am thankful I still have my partner in parenting. Our teenage son came home with an injury one morning last week, and I took one look at the gash on his face and thought it ...