ALS-causing NEK1 gene mutations disrupt cellular protein production machinery. Truncated NEK1 protein accumulates in the nucleolus, impairing ribosome biogenesis. This disruption leads to cell death ...

A new genetic study links higher levels of specific fat molecules to increased ALS risk. Fat metabolism in the body was identified as a relevant pathway in ALS susceptibility. The scientists say ...

Bulbar-onset ALS is diagnosed about four months sooner than limb-onset ALS. Limb-onset ALS is often misdiagnosed, delaying critical treatment and care. Awareness strategies for limb-onset ALS can ...

The U.S. House of Representatives has passed legislation that would renew the ACT for ALS, a landmark federal law that supports amyotrophic lateral sclerosis (ALS) research and helps people with the ...

The Muscular Dystrophy Association (MDA) brought its Engage Community Seminar to Hershey, Pennsylvania, on July 18, uniting ...

While the findings align with previous research linking smoking to ALS, researchers found no consistent evidence that heavier ...

An AI-powered brain implant helped an ALS patient regain speech by decoding brain signals. This neuroprosthesis translates ...

RAG-17 is an experimental RNA-targeting therapy designed to lower toxic SOD1 protein in people with SOD1-ALS. A six-person trial found RAG-17 was well tolerated, with no serious side effects. RAG-17 ...

A PBS documentary, "Loving John," explores a gay American Samoan man's final years with ALS. It highlights the disease's progression, caregiving challenges, and identity's role. The film emphasizes ...

I walked with our dog, Comet, on a trail in the woods behind our house. The woods felt cool out of the hot sun. Light filtered through the trees overhead as I breathed in the rich smell of summer ...

A co-designed robotic glove restored grip and independent feeding for a man with severe ALS. The soft, wearable device uses inflatable cushions, controlled by residual muscle signals. This low-cost ...