Medically reviewed by Mary Choy, PharmD Key Takeaways Nicotine has a half-life of about two hours and can stay in the blood for about one to three days. Cotinine, a byproduct of nicotine, has a ...

Nicotine's effects (and how long they last) depend on many variables Medically reviewed by Armeen Poor, MD Nicotine stays in your body for different amounts of time depending on the type of test.