In both amyotrophic lateral sclerosis and frontotemporal dementia, TDP-43, an RNA-binding protein that normally sits in the nucleus, aggregates in the cytoplasm. This same pathology also crops up in ...

The center collects, processes, stores, and distributes samples, including longitudinal samples, from its research participants. Collections are taken from donors in their 40s to late 90s in a limited ...

Microdissection of more than 130 different brain nuclei is performed on frozen brains. These samples are approved for neurochemistry, neuroendocrine, molecular biology, proteomic and genomic studies.

Not a brain bank per se, but a for-pay brain autopsy program. Some brains are kept after autopsy, and tissues from Alzheimer's, other neurological disorders and a few controls, are available to ...

This center only accepts brain tissue from patients evaluated, tested, and treated in its clinic for several years. The center keeps both healthy and diseased brains, but has more of the latter. It is ...

Somewhere, a synapse fires. Sodium and calcium flood the dendrite and trigger transcription of genes necessary for learning and memory. Within minutes, the transport protein Arc reaches the dendrite ...

Pre-Application (Letter of Intent) Submission Deadline: 5:00 p.m. Eastern Time (ET), October 23, 2026. Application Submission Deadline: 11:59 p.m. ET, November 6, 2026.

Turns out, microglia need TDP-43 to properly shape the brain's white matter during development. In the July 8 Nature Neuroscience, scientists led by Rosa Paolicelli at the University of Lausanne, ...

Could measuring proteins in the blood help pinpoint which genes underlie certain GWAS signals? By combining plasma proteomics data with genetic analyses, scientists led by Keenan Walker at the ...

Two new ApoE variants turned up in American populations. Protective variant W276C discourages ApoE from oligomerizing. Risk variant R189C promotes its lipidation. Lipidated ApoE4 disrupts microglial ...

As the outer surface of all animal cells, the plasma membrane is the foundation of cellular life. It also withstands a relentless onslaught of physical and chemical insults, which must be repaired on ...

Unlike for Alzheimer's disease, which can be diagnosed with the help of a growing suite of FDA-approved blood and cerebrospinal fluid (CSF) tests, clinicians have no easy way to diagnose or monitor ...