snmjournals.org

Differential Response to 177 Lu-PSMA-617 in Patients with Tumor Suppressor Gene–Mutated Metastatic Castration-Resistant Prostate Cancer

Genomic alterations are common in metastatic castration-resistant prostate cancer (mCRPC), but limited data exist on the response to 177Lu-PSMA-617 (LuPSMA) in patients with these aberrations. We ...
snmjournals.org

Modeling and Predicting Tumor Response in Radioligand Therapy

The aim of this work was to develop a theranostic method that allows prediction of prostate-specific membrane antigen (PSMA)–positive tumor volume after radioligand therapy (RLT) based on a ...
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Published Ahead of Print

Update to “Renal and Multiorgan Safety of 177 Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer in the VISION Dosimetry Substudy” ...
snmjournals.org

Comparison of SUVr calculations in amyloid PET brain imaging

Objectives The aim of our study was to compare two methods for SUVr calculations in amyloid PET brain imaging. Methods In a continuing study, 19 patients were imaged on a GE STE 16 slice PET/CT system ...
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18 F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging

Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of astrogliosis in the human ...
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First Human Imaging Studies with the EXPLORER Total-Body PET Scanner*

Within the EXPLORER Consortium, the construction of the world’s first total-body PET/CT scanner has recently been completed. The 194-cm axial field of view of the EXPLORER PET/CT scanner is sufficient ...
snmjournals.org

Initial Clinical Experience with [

Journal of Nuclear Medicine March 2026, jnumed.125.271031; DOI: https://doi.org/10.2967/jnumed.125.271031 ...
snmjournals.org

Utility of PSMA PET/CT in Staging and Restaging of Renal Cell Carcinoma: A Systematic Review and Metaanalysis

Journal of Nuclear Medicine May 2024, jnumed.124.267417; DOI: https://doi.org/10.2967/jnumed.124.267417 ...
snmjournals.org

Immuno-PET of Tissue Factor in Pancreatic Cancer

Upregulation of tissue factor (TF) expression leads to increased patient morbidity and mortality in many solid tumor types. The goal of this study was to develop a PET tracer for imaging of TF ...
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Preclinical 203/212 Pb-DOTA–Based Pretargeted Radioimmunotherapy in Nude Mice Bearing Established Human Colorectal Cancer Xenografts

The 203Pb (half-life [t1/2], 51.9 h) and 212Pb (t1/2 = 10.6 h) theranostic pair shows great potential for radiopharmaceutical therapy. We have developed a highly versatile pretargeted ...
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First-in-Human Phase 0 Study of AB001, a Prostate-Specific Membrane Antigen–Targeted

Journal of Nuclear Medicine March 2025, jnumed.124.269299; DOI: https://doi.org/10.2967/jnumed.124.269299 ...
snmjournals.org

CD70-Targeted Immuno-PET/CT Imaging of Clear Cell Renal Cell Carcinoma: A Translational Study

The diagnosis and surveillance of clear cell renal cell carcinoma (ccRCC) remains a clinical challenge. The high and specific expression of the cluster of differentiation 70 (CD70) in ccRCC makes it a ...