Which games in the 2025 NCAA men’s tournament will bust your bracket? Our March Madness upset predictions are in.

Here is a complete guide to picking No. 5 Michigan vs. No. 12 UC San Diego in your 2025 March Madness bracket, including updated odds and our expert predictions for the South Region game.

Can the Houston Cougars carry the third longest active winning streak in to their 5th straight Sweet 16..... or beyond?