The Jacksonville Jaguars, Buffalo Bills, and Los Angeles Chargers all clinched playoff spots in Week 16. The final spots will go to the AFC North winner and a second team from the AFC South. With two games remaining in the regular season, two AFC playoff spots remain available.

You've seen the model's best bets for Jacksonville Jaguars vs. Indianapolis Colts. Now, get against the spread, total and money-line picks for every Week 17 NFL game here, all from the model that's simulated every game 10,000 times.

We will update as more Week 17 results come in. SNF result: The 49ers beat the Bears 42-38 to set up Week 18 for the No. 1 seed. The 49ers host the Seahawks next week, with the winner claiming home field in the NFC bracket and the loser entering the playoffs as either the No. 5 or No. 6 seed.

While all but two postseason berths remain unclaimed, the battles for the top seed in each conference will also be waged in Week 18.

The Jacksonville Jaguars, led by quarterback Trevor Lawrence, face the Indianapolis Colts, led by quarterback Philip Rivers, on Sunday, Dec. 28, 2025 at Lucas Oil Stadium in Indianapolis.