The Chicago Cubs (22-15) host the San Francisco Giants (23-14) in the rubber match of a 3-game series Wednesday. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Giants vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

The Chicago Cubs have an excellent offense and rank with a .376 wOBA and third with a .220 ISO against left-handed pitchers. Still, Chicago is likely to see a splash of negative regression moving forward, and registering an extra-base hit in 10.5% of its at bats against southpaws is also likely unsustainable.

Its Wednesday, May 7 and the Giants (23-14) are in Chicago to take on the Cubs (22-15). Robbie Ray is slated to take the mound for San Francisco against Ben Brown for Chicago. These clubs have split the first two games of the series.