This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

Mitral valve prolapse (MVP) is the most common valvular heart defect. 1 Some patients with MVP are at a risk of developing malignant ventricular arrhythmias (VAs) and sudden cardiac arrest (SCA). 2 ...

Ever been to a large sporting event, such as a football or baseball game with 60,000 screaming fans? What you don’t hear through the screams is a clicking sound in the chests of about 1,500 of these ...

Genetic analysis has revealed that regulation of growth signalling and cell migration pathways could potentially be modified to limit progression from developmental defects to clinically evident valve ...

Beta-blockers may be able to treat mitral valve regurgitation medically and prevent the early stages of heart failure often seen in these patients — without valve-replacement surgery, according to ...

Mitral valve disease is when the heart’s mitral valve stops functioning correctly. This can lead to blood not flowing around the body correctly and cause several health complications. The mitral valve ...

Valvular heart disease, also called heart valve disease, occurs when you have a diseased or damaged heart valve. When your heart pumps blood, your valves open and close to keep blood flowing in the ...

The mitral valve is a flap of tissue that sits in the left side of the heart, between the left atrium and the left ventricle. It keeps blood flowing in the forward direction, from the atrium into the ...