Myofibril assembly results in a regular array of identical sarcomeres in striated muscle. Sarcomere structure is conserved across the animal kingdom, which implies that the mechanisms of myofibril ...

Titin is a giant muscle protein with a molecular weight in the megaDalton range and a contour length of more than 1 mm. Its size and location within the sarcomere structure determine its important ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, No. 16 (Aug. 15, 1991), pp. 7101-7105 (5 pages) To explore the role of titin filaments in muscle elasticity, ...

Titin is a high-molecular weight protein (3.0-3.8 MDa) in the sarcomeres of vertebrate striated muscles. A plethora of titin isoforms is expressed from the copy of a single titin gene (on chromosome 2 ...

Using new high-resolution imaging techniques, MDC researchers and colleagues have tracked titin, the body’s largest protein, in real time throughout its entire lifecycle. The method and results could ...

Imagine grabbing two snakes by the tail so that they can't wriggle off in opposite directions. Scientists at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and ...

Seung Hoan Choi, PhD, of the program in medical and population genetics at The Broad Institute of MIT and Harvard, and colleagues analyzed data from 18,526 participants from the TOPMed Program from ...

Using new high-resolution imaging techniques, MDC researchers and colleagues have tracked titin, the body's largest protein, in real time throughout its entire lifecycle. The method and results could ...

Imagine grabbing two snakes by the tail so that they can't wriggle off in opposite directions. Scientists at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and ...