GRB2 is an intracellular adapter protein essential for cell proliferation that consists of a central SH2 domain flanked by two SH3 domains 1,2,3,4,5. Classically its SH3 domains direct complex ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

Escherichia coli replicates its genome through a finely tuned ensemble of proteins that assemble at the replication fork to form the replisome. Central to this machinery are the DNA polymerase III ...

Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...

If the engines of DNA replication stay in high gear all the time, they eventually stall or even break down. Fortunately, these engines, which consist of protein complexes, have what could be called ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...

To better understand BKPyV replication and ways to prevent it, researchers in the UAB Department of Microbiology have published a single-cell analysis of BKPyV infection in primary kidney cells. Their ...