In conventional solid-phase peptide synthesis (SPPS), α-amino groups are protected with alkoxycarbonyl groups (e.g., 9-fluorenylmethoxycarbonyl [Fmoc]). However, during SPPS, inherent side reactions ...

Pharmaceutical process chemists use resolutions, or the separation of enantiomers from racemic mixtures, more than 60% of the time to generate chiral compounds. Among resolution methods, ...

The key to success in the present enantio-convergent reaction, as well as other divergent-type reactions, is the ability of the external chiral reactive species to control the selectivity. This is ...