Researchers find rare genetic mutation doesn't always result in blood cancer

Researchers have found that a genetic mutation associated with a rare group of blood cancers does not always result in ...
Medical Xpress

Mutations in two gene pairs point to a promising drug target in 5% of adult cancers

Scientists from the Cancer Dependency Map (DepMap) at the Broad Institute of MIT and Harvard and Columbia University have discovered that about 5% of adult cancers rely heavily on a gene called PELO ...

CRISPR enzyme precisely detects and shreds DNA in cancer mutations once considered 'undruggable'

In 2020, Jennifer Doudna won the Nobel Prize in chemistry for her work on the CRISPR-Cas9 gene-editing technology that allows ...
Nature

Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species

Diseases of later life represent a formidable human challenge 1. Existing hallmarks of ageing point to disparate but interconnected classes of causal factors leaving the search for unifying factors in ...
Nature

Aging alters genomic instability at endogenous mutation hotspots in mice

Aging is a critical risk factor for cancer development with genetic instability presenting as a common hallmark. Alternative DNA-forming sequences are endogenous sources of genetic instability that ...
Labroots

A 'Junk DNA' Mutation That Prevents a Disease

Only around two percent of the human genome codes for proteins, and while those proteins carry out many important functions of the cell, the rest of the genome cannot be ignored. However, for decades ...
ascopubs.org

Heterozygous Germline Fanconi Anemia–Related Gene Mutations Increase Susceptibility to Germ Cell Tumors

Germ cell tumors (GCTs) are a heterogeneous group of neoplasms that predominantly affect adolescents and young adults. Notably, geographical disparities in GCT incidence exist, with higher rates ...