In a recent study published in Immunity, researchers isolated SARS-CoV-2 spike (S) protein-targeted mAbs (monoclonal antibodies) from convalescent healthcare workers (HCWs), emphasizing the IGHV1-69 ...

Elucidation of the mechanisms that generate diversity in immunoglobulins, which was once considered a grand challenge in the field of immunology, is now regarded as a crowning achievement of the ...

Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated.

Immunoglobulins (antibodies) are Y-shaped proteins made by plasma cells that help fight infection. They neutralize invaders, tag them for macrophages, and trigger other immune responses. Each antibody ...