Extrachromosomal DNAs (ecDNAs) are circular DNA structures located in the nuclei of cells outside chromosomes. They were originally discovered in chromosome spreads of cells obtained from embryonal ...

A new scientific focus on extrachromosomal circular DNA (eccDNA) is opening transformative possibilities for disease ...

Extrachromosomal DNA (ecDNA) has emerged as a fundamental driver of tumour evolution, heterogeneity and therapy resistance. These circular, acentric DNA elements frequently harbour oncogenes, ...

Despite the diversity inherent to cancer, they all share a common theme: many things tend to go wrong. This can make it difficult to understand which factors are driving the cancer and which ones are ...

A method for parallel sequencing of single-cell extrachromosomal circular DNA (ecDNA) and full-length mRNA transcriptomes has enabled new insights into the roles of ecDNA in cancer progression, ...