Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

Fig. 4: The process of establishment of pre-RCs at an S. cerevisiae origin in which the B2 domain is separated from the A and B1 origin elements. This Review focuses on the first step in eukaryotic ...

Alcohol is broken down in the body into acetaldehyde, a toxic chemical that can damage DNA by creating interstrand crosslinks (AA-ICL). These crosslinks block DNA replication and threaten the ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

Adrian Woolfson, MD, PhD, says biology is becoming a general design and manufacturing platform poised to unlock a multi-trillion-dollar bioeconomy. Key to this transition will be the ability to write ...

The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched. A scientific team has now discovered a ...

New work shows that physical folding of the genome to control genes located far away may have been a critical turning point for life on Earth. For evolutionary biologists, what most distinguishes the ...