First 3D views of human cone opsins reveal how daylight vision reacts so fast

The retina of the human eye contains 6–7 million cone cells. These cells contain light-sensitive proteins known as cone ...
Nature

Microglial CX3CR1 deficiency regulates the selective vulnerability of cone photoreceptors via STAT3/CCL–ACKR1 signaling in the mouse retina

Animals were anesthetized with a mixture of ketamine hydrochloride (100 mg/kg) and xylazine (50 mg/kg), and eyeballs were quickly enucleated, followed by separating the retina from vitreous and sclera ...
Medical Xpress

Solving a mystery in vision science: Zebrafish study shows how retinal cells maintain spacing needed for optimal vision

In vertebrate retinas, specialized photoreceptors responsible for color vision (cone cells) arrange themselves in patterns known as the "cone mosaic." Researchers at the Okinawa Institute of Science ...
EurekAlert!

Study shows how retinal cells know when to keep their distance

(Left panels) Cone mosaic pattern in adult zebrafish showing a lattice-like regular arrangement of four cone cell types. (Right panels) Cone mosaic pattern in fish lacking the Dscamb gene on either or ...
Nature

Molecular mechanisms limiting the AAV gene therapy treatment window in mouse models of blue cone monochromacy

In the human retina, long (L-, red) and medium (M-, green) wavelength-sensitive cones comprise ~95% of the total cone population and are concentrated in the fovea, a small central region in the retina ...
HUB

How did humans develop sharp vision? Lab-grown retinas show likely answer

Humans develop sharp vision during early fetal development thanks to an interplay between a vitamin A derivative and thyroid hormones in the retina, Johns Hopkins University scientists have found. The ...