Apical localisation of CFTR protein and its chloride channel activity strictly depend on interactions of its PDZ (for postsynaptic density 95/disclarge/zona occludens)-interacting domain in the C ...

New research findings add further clarity to a question that has polarized the cystic fibrosis (CF) research community. It is well established that people with cystic fibrosis have two faulty copies ...

KB407’s positive set of results presented at ATS 2026 follows a set of similar positive results that were announced for the ...

Researchers studying the root cause of cystic fibrosis have made a major advance in our understanding of silent gene changes with implications for the complexity of cystic fibrosis. Cystic fibrosis is ...

The drug is a small molecule with a novel mechanism of action, say David Bedwell, Ph.D., and Steven Rowe, M.D., MSPH, co-senior authors. Bedwell is professor and chair of the University of Alabama at ...

Edited By: Karen Young Kreeger C.L. Ward, S. Omura, R.R. Kopito, "Degradation of CFTR by the ubiquitin-proteasome pathway," Cell, 83:121-7, 1995. (Cited in nearly 50 publications as of March 1997) ...

January 12, 2016 CHAPEL HILL, NC - It is well established that people with cystic fibrosis (CF) have two faulty copies of the CFTR gene, but debate continues on the question of whether certain ...

Cystic fibrosis is a common life-shortening inherited disease that affects over 70,000 people worldwide, the majority of whom are children and young adults. Individuals living with cystic fibrosis ...

It is well established that people with cystic fibrosis (CF) have two faulty copies of the CFTR gene, but debate continues on the question of whether certain symptoms of the airway disease are caused ...