The Arizona Cardinals have yet another blemish on their record, this time falling to the Los Angeles Rams for their second loss in three games to begin the new season. Despite missing DeAndre Hopkins, there were plenty of other weapons to satisfy ...

The third-year Seattle receiver had his worst game of the year against the Cardinals, and that was still a good game.

See who's in and who's out for the Week 12 matchup between the Jacksonville Jaguars and Arizona Cardinals on November 23, 2025.

The Arizona Cardinals, losers of seven of their last eight games, hope to regroup against a tough Jacksonville Jaguars team. The 3-7 Cardinals and 6-4 Jaguars kick off from State Farm Stadium at 4:05 p.m. ET (2:05 p.m. Arizona time). The Jags have won two of three and are coming off a 35-6 win over the LA Chargers.

There will no return to the field for Arizona Cardinals running back Trey Benson this week. Designated to return on Wednesday from injured reserve and able to practice for the first time since he suffered a knee injury in Week 4, Benson was ruled out of Sunday's game against the Jacksonville Jaguars at State Farm Stadium in Week 12.

Let's take a look at four things to know about Jaguars vs. Cardinals along with a prediction for the Week 12 game.

The Arizona Cardinals keep finding weird new ways to lose games as a once-promising season has turned into a rough slog with six games remaining