Winning the AFC South for a third straight time and potentially reaching a Super Bowl is the goal for Houston, which opens the season on the road with a major test: The Los Angeles Rams. Taking on an NFC contender, who has the fifth best odds to win the NFC, according to ESPN BET (+1000), will present challenges.

Houston's full 2025 schedule was released Wednesday night, marking a highly anticipated annual event on the NFL calendar. The Texans will begin their third season with quarterback C.J. Stroud by traveling to the Los Angeles Rams and will conclude their regular season with a Week 18 divisional clash against the Indianapolis Colts.