The Jacksonville Jaguars have already clinched a playoff berth. They now face the Indianapolis Colts eyeing improved seeding. Follow for live updates.

You've seen the model's best bets for Jacksonville Jaguars vs. Indianapolis Colts. Now, get against the spread, total and money-line picks for every Week 17 NFL game here, all from the model that's simulated every game 10,000 times.

What just happened? What does it mean? What are the pertinent factors (and, perhaps, tiebreakers) prominently in play as each conference's seven-team bracket begins to crystallize? All will be explained and analyzed up to the point when the postseason field is finalized Sunday,

The Jacksonville Jaguars, led by quarterback Trevor Lawrence, face the Indianapolis Colts, led by quarterback Philip Rivers, on Sunday, Dec. 28, 2025 at Lucas Oil Stadium in Indianapolis.

Video highlights, recaps and play breakdowns of the Jacksonville Jaguars vs. Indianapolis Colts NFL game from December 28, 2025 on ESPN.